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Sheybani Lab

Precision acoustic engineering for next-generation cancer treatments

Our Work

In the Sheybani Lab, we are driven by the idea that sound can be a powerful form of medicine.

Our research advances focused ultrasound (FUS) technology as a non-invasive, non-ionizing, and spatially targeted platform for treating disease deep within the body without surgery. We are engineering FUS paradigms to reprogram tumor immunobiology and power the next generation of cancer immunotherapies with precision and control. By engineering the physics of sound waves to enable safer and more effective cancer treatments, we aim to redefine what is possible in cancer care. Our mission is made possible through a vibrant network of scientific, clinical, and community collaborators.

Core Pillars

Precision

Drug Delivery

Augmenting delivery and amplifying the effect of  immunotherapies in high-risk cancers

Immune Modulation

Studying how acoustic stimuli reshape interaction between tumors and the immune system 

Biomarker Discovery

Discovering non-invasive biomarkers for treatment guidance and adaptation 

Theranostic

Strategies

Utilizing advanced molecular imaging techniques for functional closed-loop feedback

Recent Publications

CAR-T cell therapy in brain malignancies: obstacles in the face of cellular trafficking and persistence

Serge Yaacoub, Elton Vannoy, Stefanyda Maslova, Abigail Haffey, Khatereh Khorsandi, Natasha Sheybani, Dalia Haydar

Frontiers in Immunology

2025

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